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Abbreviations DR diabetic retinopathy VEGF vascular endothelial growth factor DN diabetic nephropathy CVD cardiovascular disease COPD chronic obstructive pulmonary disease NPDR non-proliferative DR PDR proliferative DR GSH glutathione ROS reactive oxygen species ICAM-1 intercellular adhesion molecule-1 VCAM-1 vascular cell adhesion molecule-1 iNOS inducible nitric oxide synthase IL, interleukin TNF-α tumor necrosis factor α MCP-1 monocyte chemoattractant protein-1 NF-κB nuclear factor-κB NO nitric oxide